منابع مشابه
Protein Folding: Importance of the Anfinsen Cage
To survive in a competitive world, cells must optimise both the rate of production and the yield of correctly folded proteins. Partially folded polypeptide chains, either newly made by ribosomes or emerging from mature proteins unfolded by stress, run the risk of aggregating with one another to the detriment of the organism, the worst consequences being neurodegenerative diseases such as Alzhei...
متن کاملGroEL: More than Just a Folding Cage
The chaperonin GroEL has been thought of as an important but passive player in protein folding, providing an encapsulated environment that allows folding to proceed unimpaired by aggregation. In this issue, Tang et al. (2006) redesign the GroEL central cavity and show that the chaperonin cage can alter the rate of folding and, for some proteins, could even alter the folding mechanism.
متن کاملInternal friction in the ultrafast folding of the tryptophan cage
Protein folding is a diffusional process, and the speed of folding is controlled by the frictional forces that act on the polypeptide chain. Several previous studies have suggested that the bulk viscosity of the solvent is the only important source of friction in folding reactions. By contrast, our studies of the folding dynamics of the Tryptophan Cage, a small, ultrafast-folding protein, show ...
متن کاملDynamic Folding Pathway Models of the Trp-Cage Protein
Using action-derived molecular dynamics (ADMD), we study the dynamic folding pathway models of the Trp-cage protein by providing its sequential conformational changes from its initial disordered structure to the final native structure at atomic details. We find that the numbers of native contacts and native hydrogen bonds are highly correlated, implying that the native structure of Trp-cage is ...
متن کاملFolding Dynamics and Pathways of the Trp-Cage Miniproteins
Using alternate measures of fold stability for a wide variety of Trp-cage mutants has raised the possibility that prior dynamics T-jump measures may not be reporting on complete cage formation for some species. NMR relaxation studies using probes that only achieve large chemical shift difference from unfolded values on complete cage formation indicate slower folding in some but not all cases. F...
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ژورنال
عنوان ژورنال: Journal of Cell Biology
سال: 2006
ISSN: 1540-8140,0021-9525
DOI: 10.1083/jcb.1736rr4